ABSTRACT
Otto Warburg in 1956 rst proposed his famous hypothesis for the origin of cancer. Since then, the novel tools of molecular medicine have considerably deepened our understanding of the roles of mitochondria in tumor biology and, perhaps most importantly, pointed to these organelles as very intriguing targets for anticancer therapy (Gogvadze et al. 2008; Ralph et al. 2010). Thus, the “old” ndings of Otto Warburg are now at the center pedestal of molecular medicine and are being further developed by researchers to improve our understanding of cancer biology and therapy (Kaelin 2009; Neuzil et al. 2010). Mitochondria, traditionally considered (and rightly so) as tiny powerhouses that respire to supply the cells in the body with their energy, are also vessels lled with an array of weaponry that can be unleashed
4.1 Introduction .................................................................................................... 55 4.2 Brief Classication of Mitocans ..................................................................... 56 4.3 Anticancer Drugs that Target the Mitochondrial Complexes ......................... 61
4.3.1 Complex I ............................................................................................ 62 4.3.2 Complex II ..........................................................................................68 4.3.3 Complex III ......................................................................................... 73 4.3.4 Complex IV ......................................................................................... 76 4.3.5 Complex V ..........................................................................................77
