ABSTRACT

The brain controls the body’s functions through cell signaling and other regulatory pathways. Lipids are hydrophobic biomolecules composed of long hydrocarbon chains. Classes of lipids include but are not limited to phospholipids, triacylglycerols, steroids, and eicosanoids. The brain is abundant in polyunsaturated fatty acids, making lipids vulnerable to oxidation as the brain consumes more than 30% of inspired

Introduction ............................................................................................................ 329 Redox Proteomics, Lipid Peroxidation, and Neurodegenerative Disorders .......... 330 Lipid Peroxidation ................................................................................................. 330 Importance of Lipid Peroxidation and Its Effects in Neurodegenerative Diseases .................................................................................................................. 334

Alzheimer’s Disease .......................................................................................... 334 Lipid Peroxidation during AD Progression .................................................. 334

Parkinson’s Disease ........................................................................................... 337 Animal Models ............................................................................................. 339 Lipid Peroxidation in PD .............................................................................. 341

Amyotrophic Lateral Sclerosis .......................................................................... 341 Lipid Peroxidation and Redox Proteomics in ALS ...................................... 342

Huntington’s Disease ........................................................................................ 343 Lipid Peroxidation in HD .............................................................................344 Redox Proteomics of HNE-Bound Proteins in HD ......................................344