ABSTRACT
Dermatological conditions are explored fully in the medical literature, but this text will become the standard reference on the topmost layer of the skin. It distinguishes itself by its scholarship, its comprehensive treatment of all aspects of this specific subject, its accessibility and especially its focus. The editors have brought together international researchers to give an evidence-based presentation of the stratum corneum. From consumer demands and dandruff to aging and water absorption, these experts profile everything about this part of the skin, and they do so in a highly detailed but straightforward way. Dermatologists will find The Essential Stratum Corneum to be the standard text on the subject.
Ultrastructural aspects of stratum corneum. Formation and function of the stratum corneum. Update on desquamation: First evidence for the presence of endoglycosidase activity in the human stratum corneum. Purification and characterization of heparanase 1 (Hpa1). Crossing the barrier. Understanding and measuring the optics that drive visual perception of skin appearance. Environmental threats to the stratum corneum. The scale of the problem. Lipid organization and barrier function. Corneodesmosomal proteins are proteolysed in vitro by both SCTE and SCCE, two proteases which are thought to be involved in desquamation. Calmodulin like skin protein (CLSP): A new marker of keratinocyte differentiation. Association of hsp27 with epidermal structural proteins and its expression in keratinization disorders. The single gel-phase model and the membrane folding model for skin barrier structure, function and formation. Comparison of cutaneous bioavailability of cosmetic formulations containing caffeine or alpha-tocopherol applied on human skin models or human skin ex vivo at finite doses. Structure of multi-phasic dermal formulations and the influence of the structure and of vehicle evaporation on transdermal permeation. Transdermal iontophoresis of leuprolide in vitro under constant voltage and constant current conditions: Physicochemical modeling and the effect of adjuvants. Quantification of vitamin E-acetate (cosmetic formulations) in the stratum corneum of an in-vitro model by tape stripping, UV-spectroscopy and HPLC-method. The effect of extraction and NMF treatment on the water handling capability of stratum corneum as measured by TEWL and MAT. Electrical impedance. A method to evaluate the ability to betaine to reduce the skin irritating effects of detergents. Electrical capacitance measurement of the stratum corneum hydration: Comparison with the dermopharmacokinetics of the active moiety. Evaluation of surfactant effects on stratum corneum using squamometry, transepid
