ABSTRACT
CONTENTS 15.1 Introduction 387 15.2Strategy388 15.3Challenges of Regeneration 392
15.3.1Regeneration Is a Process and Not a Trait 392 15.3.2Origin of the Regeneration-Competent Cells 393 15.3.3Tools to Identify Subpopulations of Regeneration Progenitor Cells 396 15.3.4Models of Limb Regeneration397
15.4 Way Forward 399 15.4.1We Need Regeneration-Competent Cells 399 15.4.2We Need to Control DiŽerentiation 401 15.4.3We Need to Control the Information …at Leads to the Right Tissues
Being in the Right Place401 References402
388
the remarkable progress in our ability to discover and manipulate biological processes has provided the tools and resources needed to make human regeneration a reality. In this chapter, we argue that all that is now standing in the way of successful regeneration is the lack of a feasible strategy to achieve that outcome. In theory, there may be many ways to develop such a strategy; however, we already know of one way that works extraordinarily well, which is the way that highly regenerative animals such as the salamander do it. …erefore, we argue that the strategy that is most likely to achieve success is to understand how salamanders are able to regenerate so well.
