ABSTRACT
For several decades, scientists studying neural development were limited by two famous dogmas. First, neurons and glial cells (e.g., astrocytes, oligodendrocytes) are generated by distinct progenitors. Second, once development is complete, no new neurons are generated in the adult mammalian brain. Herein, cellular labeling methodologies are summarized that have convincingly overcome the limitations imposed by these dogmas. In particular, a fl uorescent protein reporter system is described that has enabled the identifi cation and visualization of neural stem cells
Department of Physiology, Keio University School of Medicine, Tokyo, Japan. *Corresponding author: hidokano@a2.keio.jp
List of abbreviations after the text.
