ABSTRACT
The original characterization of the mechanisms underlying regulation of the ßAR signalling efficacy was carried out mainly with the ß2AR, with the implicit assumption that similar-if not identical-processes would also be involved in the regulation of ß1and ß3AR responsiveness. Data gathered during the past five years or so invalidated this assumption. Indeed, subtype-specific regulatory processes have been delineated for the three receptors. In particular, the regulatory profile of the ß3AR was found to be dramatically different from that of the ß2AR, and the molecular basis of the differences have begun to be unravelled.
