ABSTRACT
Induction of apoptosis 612 Antiangiogenesis613 Suicide gene therapy 613 Immunogene therapy613 Replicating, tumor-selective vectors 614 Clinical trials of immunogene therapy 614 Gene-modified autologous T-cell therapy 616 Conclusions 616 References 616
transduction of a large number of cells within the pleural cavity. e patterns of uid drainage from the pleural space through vascular and lymphatic channels ensure rapid systemic uptake of secreted gene products. Access to the pleural space is relatively easy and safe via thoracostomy tubes, indwelling tunneled catheters, and small-diameter thoracoscopes. Fusion of the pleural surfaces (i.e., pleurodesis) is quite benign, and in some instances (e.g., recurrent symptomatic malignant pleural eusions) may be desirable.
