ABSTRACT

Epilepsy is a chronic condition that is characterized by recurrent and unprovoked seizures. A seizure can be defined clinically as “intermittent paroxysmal, stereotyped disturbance of consciousness, behavior, emotion, motor function, perception, or sensation, which may occur singly or in combination and is thought to be the result of abnormal cortical neuronal

CONTENTS

5.1 Introduction ................................................................................................ 123 5.2 Types of Epileptic Seizures ....................................................................... 124

5.2.1 Generalized Seizures..................................................................... 124 5.2.2 Partial Seizures .............................................................................. 125

5.3 Electroencephalography and Epileptic Seizure Detection .................. 125 5.3.1 Seizure Detection Algorithms ..................................................... 126

5.3.1.1 Seizure Event Detection ................................................. 126 5.3.1.2 Seizure Onset Detection ................................................ 131

5.4 Development of a Seizure Detection System Using the Singular Values of EEG Signals ............................................................................... 134 5.4.1 Database .......................................................................................... 134 5.4.2 Machine-Learning-Based Seizure Detection System

Using SVD ....................................................................................... 135 5.5 EEG Time-Series Analysis ........................................................................ 136 5.6 Multivariate Measures .............................................................................. 137 5.7 Principal Component Analysis ................................................................ 138 5.8 Closed-Loop Seizure Prevention System ............................................... 138 5.9 Summary ..................................................................................................... 139 References ............................................................................................................. 139

discharges.” The exact type of seizure will depend on where it starts and then spreads within the brain. Abnormalities in synaptic transmission, neuronal excitability, voltage gated ion channels, neuronal proteins, and gene expression are all implicated in the pathogenesis of epilepsy.