ABSTRACT
This conclusion presents some closing thoughts on the key concepts discussed in the preceding chapters of this book. The book presents the different functions of glutamine (Gln) in animals and humans. Gln functions go beyond that of a simple metabolic fuel or protein precursor; Gln is both a nutrient and a signaling molecule. The book examines new data on Gln synthetase regulation in the small intestine and colon and focuses on the roles of Gln in neurotransmission. Gln has a function specific to the nervous system and abnormalities of its metabolism are central to the pathogenesis of selected central nervous system diseases. The book describes chronic metabolic acidosis and renal injury and explains how nutrition and Gln can modulate the immune response during acute and chronic exercise. Gln is a key substrate for the splanchnic bed and a specific nutrient in gastrointestinal research with aging.
