ABSTRACT
Abstract .................................................................................................................. 106 Introduction ............................................................................................................ 106 Characteristics of Hydrogen Sulde ...................................................................... 106
Chemical Properties of H2S............................................................................... 106 Toxicological Prole of H2S ............................................................................. 107 H2S-Releasing Donor Molecules ...................................................................... 107
Regulation of Hydrogen Sulde Production and Metabolism in the Liver ........... 109 Pharmacological Effects of Hydrogen Sulde ....................................................... 113 Hydrogen Sulde in Cell Signaling ....................................................................... 113
Reactions of H2S with Metal Ions ..................................................................... 113 Protein S-Sulfhydration ..................................................................................... 114 H2S as an Antioxidant and Reducing Agent ...................................................... 116
Modulation of Mitochondrial Function by Hydrogen Sulde ............................... 117 H2S as a Mitochondrial Poison.......................................................................... 118 H2S as an Inorganic Source of Energy .............................................................. 119 H2S as a Regulator of Mitochondrial cAMP Homeostasis ............................... 121
Pathophysiological Roles of Hydrogen Sulde in the Liver .................................. 121 Therapeutic Effects of H2S in Diabetic Liver Dysfunction ............................... 122 H2S in Liver Ischemia/Reperfusion Injury ........................................................ 123 H2S in Critical Illness ........................................................................................124
