ABSTRACT

Adverse events are the unintended consequences or failures of drug intervention. ese events needed to be detected, understood, predicted, and, if possible, prevented or ameliorated. Unfortunately, most eective drugs also have some unintended consequences. It is important, therefore, to understand everything the literature is saying about a class of drugs in order to recognize and anticipate downstream consequences of protein modulation, and, if possible, nd ways to mitigate the adverse event.