ABSTRACT

Traumatic brain injuries (TBIs) pose a great health concern. In the United States alone, nearly 2 million people per year will have suffered a TBI. In the civilian population, most TBIs result from falls (35.2%), motor vehicle accidents (17.3%) and assault (10%). Both youth and adult athletes may suffer multiple concussions (https://www.cdc.gov/traumaticbraininjury/ statistics.html). They are often exposed to a variety of combat traumas. More than 30,000 military personnel suffered a TBI in 2012. Another 13,000 or more people had a TBI in 2013 (https://www.dvbic.org/dod-worldwidenumbers-tbi). TBI is highly variable and characterized by several severities

1 Branch of Brain Trauma Neuroprotection and Neurorestoration, Center for Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.