ABSTRACT
Gastric outlet obstruction in the newborn may be due to pyloric atresia (PA), antral web, or hypertrophic pyloric stenosis. The latter is most common cause of gastric outlet obstruction. Though a sure etiology is still unknown, mucosal desquamation leading to gastric outlet obstruction has been suggested to play a role, mainly in patients with associated epidermolysis bullosa (EB). Prenatal diagnosis of PA can be suspected when polyhydramnios is present and associated with a dilated stomach. Prenatal diagnosis of PA and EB can be performed in pregnancies at risk for recurrence of this syndrome. The newborn with complete pyloric obstruction presents shortly after birth with persistent nonbilious vomiting and epigastric distension. Usually, newborns are referred to the hospital and admitted within the first 48 hours of life. They are generally in good physical condition, except those with EB. Gastrostomy is not strictly necessary but can be considered in certain instances.
