ABSTRACT
Despite a lot of efforts in the past decade, medicinal application of oligonucleotides is still hampered by insufficient delivery of oligonucleotides to the proper site of action, and a low ratio of specific to non-specific interactions. Several modifications of oligonucleotides have been adopted to overcome these issues (see also Chapters 2, 3 and 4). Though such strategies partially solved the problems, an ideal and/or general strategy that circumvents them has not yet been established.
