ABSTRACT
Oligonucleotides as drugs have attracted substantial interest in recent years. Sequencespecific interference with RNA function by complementary Oligonucleotides, as proposed by Belikowa et al. (1973) and experimentally investigated by Stephenson and Zamecnik (1978) and Zamecnik and Stephenson (1978), resulted in the ‘antisense approach’. Here the expression of a specific gene is blocked on the mRNA level by a complementary oligonucleotide called antisense oligonucleotide (Figure 2.1).
