ABSTRACT
Toxicities of hemoglobin (Hb) solutions, which have been demonstrated in nu merous animal resuscitation models, prominently include fever, hypertension, thrombocytopenia, activation of the complement and coagulation cascades, dis seminated intravascular coagulation with parenchymal organ damage, reduced tolerance to sepsis, susceptibility to bacterial infections, reticuloendothelial cell blockade, and lethal toxicity (1-10). In addition, recent clinical trials of cross linked Hb have been associated with production of hypertension and gastroin testinal dysmotility.