ABSTRACT

Perhaps the most sophisticated interfaces available on the WWW are the GenBank Entrez (Fig. 11.7) system and the EMBL Sequence Retrieval

Database Address

EMBL/Nucleic https://www.ebi.ac.uk/ebi_docs/embl_db/ebi/ Acids toopembl.html

EMBL SRS https://www.ebi.ac.uk/srs/srsc GenBank https://www.ncbi.nlm.nih.gov/Web/Search/

index.html GenBank Entrez https://www3.ncbi.nlm.nih.gov/Entrez/index.html PIR https://www.gdb.org/Dan/proteins/pir.html PUMA https://www.mcs.anl.gov/home/compbio/PUMA/

Production/puma.html RDP https://rdp.life.uiuc.edu/ rRNA Server h ttp ://rrna.uia.ac.be/ SwissProt https://www.ebi.ac.uk/ebi_docs/swissprot_db/

swisshome.html

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System (SRS) (Fig. 11.8). Both allow users to search the respective databases by using simple query forms that can provide on-line help if necessary. Some query fields can support complex Boolean operations. In both cases, the results of an initial search can be used as links to other data resources. For example, the Entrez system provides links from GenBank to the molecular biology subset of the bibliographic database Medline. In addition to the direct citation for a sequence, Medline also identifies related publications (called neighbors), which can be used as Entrez links to other sequences back in GenBank. The EMBL SRS system provides links from the gene sequence database to over 25 other databases.