ABSTRACT
Merrifield's invention of solid-phase peptide synthesis (SPPS) revolutionized the field of peptide chemistry [I]. Prior to the development of SPPS, peptides were synthesized via classical solution-phase methods, which are customarily quite tedious and time consuming, and require considerable expertise [2,3]. In solution-phase syntheses, purification and characterization are required after each step, and the solubility of the peptide worsens and becomes more unpredictable with increased chain length. With the advent of SPPS, particularly with aid of automated instruments, the time required for the synthesis of peptides has been reduced from weeks or months to hours or days.
