ABSTRACT
Combinatorial chemistry as a modality for the parallel synthesis of large numbers of potential pharmacophores constructed from a single template has now gained widespread acceptance and usage in the drug discovery process [11. Because of the rapid evolution of the technology, there is, as demonstrated by the previous chapters in this book, a need for a continuous update and review of the science. The application of these massive parallel synthetic approaches has placed significant pressure on the analyst, who is required to provide the synthetic chemist with timely decision-making information associated with both the identity and purity of the products produced. It is therefore the intention of this chapter to highlight some of the pressures these automated synthetic technologies [2] cascade upon the analytical function and the strategy that we have developed to meet these requirements.
