ABSTRACT
I. INTRODUCTION The development of effective, high-efficiency enantiomeric separations is a tremendous success story. In a relatively short period of time (from the early 1980s to the mid-1990s), this field evolved from an academic novelty to a widely useful collection of related techniques that are used routinely in many branches of science and technology. This success is a tribute to the relatively few researchers who developed the field and whose work provided the impetus for the U.S. Food and Drug Administration's issuance of new guidelines for the development of stereoisomeric drugs in 1992 [1].
