ABSTRACT
The pathogenesis of RADS is uncertain but most likely involves generation of a localized inflammatory response in the airways following epithelial and subepithelial mucosal in jury. The epithelial damage leads to increased epithelial permeability and exposes subepi thelial irritant receptors to inhaled and environmental influences, including cold air, smoke, pollutants, and nonspecific irritants. Stimulation of the subepithelial receptors can cause nonspecific bronchial hyperreactivity and bronchospasm.