ABSTRACT
Conflicting data however, the effects on more mature cells like CFC-G or CFU-M (60). In some reports an inhibition of monocyte/ macrophage colony formation in the presence of RA has been described (60,61). Others have found a stimulation of macrophage development (62,63). Similarly, opposing effects on granulocyte colony formation have been described (60,64). In "''"''."''vn, several reports did not find a influence of RA on CFU-G or CJFUOM (18,65,66). immunomagneticaliy isolated CD34+ cells (67), we
found a marked inhibition of G~CSF-induced colony formation and growth in liquid culture of these hematopoietic progenitor cells in the presence of RA (Smeland et al., submitted).
