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has been used in various fields of the survey. Proteins showing specific affinity to STX, such as sodium channel proteins, are known to possess an important role in neurophysiology. Affinity columns prepared with agar ose resin bound with STX could be a useful tool for isolating these proteins more easily and rapidly. Toxification of shellfish by PSP toxins is now a world-wide problem. Monitoring has been conducted in many countries to avoid the marketing of toxic shellfish. For such monitoring, a mouse bioassay (Hollingworth and Wekell 1990) is used in most of the countries as the official method of analysis. The mouse assay for PSP toxins is a simple and reliable method, but it has problems because it is an animal assay, especially because continued use of an animal assay is increasingly difficult to justify on ethical grounds. Various alternative methods have been developed for analysis of PSP toxins, such as HPLC methods (Oshima 1995b, Sullivan et 1985), binding assay (Davio and Fontelo 1984, Deucette et al. 1994) and
DOI link for has been used in various fields of the survey. Proteins showing specific affinity to STX, such as sodium channel proteins, are known to possess an important role in neurophysiology. Affinity columns prepared with agar ose resin bound with STX could be a useful tool for isolating these proteins more easily and rapidly. Toxification of shellfish by PSP toxins is now a world-wide problem. Monitoring has been conducted in many countries to avoid the marketing of toxic shellfish. For such monitoring, a mouse bioassay (Hollingworth and Wekell 1990) is used in most of the countries as the official method of analysis. The mouse assay for PSP toxins is a simple and reliable method, but it has problems because it is an animal assay, especially because continued use of an animal assay is increasingly difficult to justify on ethical grounds. Various alternative methods have been developed for analysis of PSP toxins, such as HPLC methods (Oshima 1995b, Sullivan et 1985), binding assay (Davio and Fontelo 1984, Deucette et al. 1994) and
has been used in various fields of the survey. Proteins showing specific affinity to STX, such as sodium channel proteins, are known to possess an important role in neurophysiology. Affinity columns prepared with agar ose resin bound with STX could be a useful tool for isolating these proteins more easily and rapidly. Toxification of shellfish by PSP toxins is now a world-wide problem. Monitoring has been conducted in many countries to avoid the marketing of toxic shellfish. For such monitoring, a mouse bioassay (Hollingworth and Wekell 1990) is used in most of the countries as the official method of analysis. The mouse assay for PSP toxins is a simple and reliable method, but it has problems because it is an animal assay, especially because continued use of an animal assay is increasingly difficult to justify on ethical grounds. Various alternative methods have been developed for analysis of PSP toxins, such as HPLC methods (Oshima 1995b, Sullivan et 1985), binding assay (Davio and Fontelo 1984, Deucette et al. 1994) and
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