Effects of Estrogen and Raloxifene, a Selective Estrogen Receptor Modulator, in Animal Models of Vascular Injury

A large body of epidemiological data supports the ability of estrogen replacement therapy to protect postmenopausal women from cardiovascular disease (Barrett-Connor and Bush, 1991; Stampfer and Colditz, 1991). These findings are in good accord with the observations that prior to menopause women are relatively protected from estrogen as compared to age-matched men, while in the

* Corresponding author, Tel.: 0013172765754, Fax: 0013172770892, E-mail: kauffman_raymond_f@lilly.com.