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Figure 1 Partial karyotypes showing the t(9 ;22) typical of CML (above), and a three-way translocation which also produces a Ph chromosome (below) (see text for description) . A. Peripheral blood smear showing granulocytosis, with left shift, " myelocyte bulge," and basophilia. B . Bone marrow section showing a hypercel­ lular bone marrow with marked granulocytic proliferation with maturation.