ABSTRACT
Although conventional cytogenetics via various banding techniques is a highly informative and established diagnostic procedure which enables one to inspect the entire human genome at a glance, its application i s restricted to dividing cells . Interpretation is also difficult when one en counters a suboptimal specimen with an inadequate number of high-quality metaphases . The advent of fluorescent in situ hybridization (FISH), made possible by the explosion in recombinant DNA technology, offers an un precedented opportunity for the analysis of a large number of nondividing cells in the interphase stage. Thus , FISH is sometimes called interphase cytogenetics .
