ABSTRACT

Fc-yRIII,likeFc-yRII,haslowaffinityforbindingmonomericlgG(Kct<w-7M)(78). However,recentdata(53)suggeststhatthemacrophageFc-yRIIIreceptormayhaveahigher affinitythanoriginallythought.ThebindingspecificityforhumanlgGindicatesthatsubclasses IgGlandIgG3bindaboutequallywell,whereaslgG2andlgG4donotbind(78,79).