ABSTRACT
Despite the advances in diagnosis, management, and care of nail diseases, much remains unknown about the initial nail development and its morphogenesis. Nail changes are reported in many genodermatoses. They might be isolated or combined with other organs or tissue features. In many genetic disorders, the diagnosis is based on the anomalies of other organs. Rarely, changes in nails are characteristic, representing a major clue for the diagnosis. The description of the nail feature represents a striking difculty. Different terms used to describe are sloppy, such as onychodystrophy or onychodysplasia. Onycholysis is rarely used. The number of nails involved is mentioned rarely.
