ABSTRACT
The physiological and psychological effects of chemical exposure complicate effective execution of the tasks. It is at this critical stage in the triage of chemical casualties that experimental results can, with contextual translation, serve to augment the triage procedure. Physiological data gathered from animal models can be used to augment triage strategies intended for different scenarios. Within the realm of physiological data analysis, approaches to identifying trends and values that are predictive of outcome or indicative of exposure are often chosen based on three binary factors: exploratory/confirmatory data analysis, statistical/practical significance, and reductionism/non-reductionism. A wide variety of inhalation toxicology exposure models, such as whole-body, head-only, nose-only, lung-only, and partial lung, are well described in the literature and have been used to generate data for a number of laboratory animal species, including mice, rats, dogs, and non-human primates. Gaining insight into different mechanisms and symptomology requires data sourced from either case studies of human exposure or experimental exposure models.
