ABSTRACT
INTRODUCTION The size enlargement of primary particles has been carried out in the pharmaceutical industry in a variety of ways. One of the most common unit operations used in the pharmaceutical industry is the fluid-bed processing where the granules are produced in a single piece of equipment by spraying a binder solution onto a fluidized powder bed. This process is sometimes classified as the one-pot system because granulation and drying are carried out in the same equipment. The batch fluid bed granulation process is a well-established unit operation in the pharmaceutical industry; however, other process industries, such as food, nutraceutical, agrochemical, dyestuffs, and other chemical industries, have adopted fluid-bed granulation process to address particle agglomeration, dust containment, ease of material handling, and modifying particle properties to provide dispersibility or solubility to products, among other product enhancements.
