ABSTRACT

The most common malignancy of genital skin is squamous cell cancer (SCC). SCC accounts for approximately 90% of malignant tumors of the vulva and 5% of all gynecological cancers1. It represents 95% of penile cancers and 2% of all male genital cancers2. The sexually transmitted human papillomavirus (HPV) is mostly responsible for the high rate of SCC, as well as vulvar and penile intraepithelial neoplasias, essentially equivalents to SCC in situ. Although the other common skin cancers, basal cell cancer and melanoma, rarely present in the genitalia, they should be included in the differential diagnosis in certain clinical presentations and in at-risk patients. Extramammary Paget’s disease is a rare skin cancer that has a proclivity toward the vulva when it occurs. Kaposi’s sarcoma presents in certain at-risk populations and occasionally presents with a primary genital lesion. Finally, there are case reports of rare skin cancers presenting in the genitalia such as dermatofibrosarcoma protuberans and leiomyosarcoma.