ABSTRACT
Figure 8. Effects of 5-HT receptor antagonists on the fluvoxamine (Flu; 30 mgkg - 1 , i.p.)-induced changes in long-term potentiation (LTP) in the CAl field. The 5-HT] A receptor antagonist NAN 190 (NAN; 0.5 mgkg - 1 , i.p.), the 5-HT4 receptor antagonist GR 113808 (GR; 20 /xgrat-1, Lev.) or the 5-HT7 receptor antagonist DR 4004 (DR; 10 /zgrat-1, Lev.) was applied 10 min before fluvoxamine, which was applied 20 min before titanic stimulation (Tetanus). (A) Time course effects of 5-HT receptor antagonists on fluvoxamine-induced changes in LTP formation. Values are expressed as a percentage of the baseline level before titanic stimulation. The number of rats tested is presented in Table 1. (B) The area under the curves (AUC; x 103% min) of the PS amplitude during the 60-min period after titanic stimulation. The number in each column indicates the number of rats tested. *p < 0.05 vs. control. #p < 0.05 vs. fluvoxamine alone.
