ABSTRACT

Figure 2. Antagonistic effect of ifenprodil on the antinociceptive action induced by spermine (A) and spermidine (B) in the mouse capsaicin test. Ifenprodil was co-administered intrathecally with each polyamine. Capsaicin was injected 5 min after intrathecal administration. The data are given as means and S.E.M. for groups of 10 mice. **/? < 0.01 when compared to CSF-treated controls. when compared to each polyamine alone. For other details see Fig. 1.