ABSTRACT

Although many new drugs are synthesised to treat cancer diseases, the clinical potential of such structures is subject of certain therapeutic and toxicological limitations, mainly depending on the physicochemical properties of the drug. Among them, the most important are the simple barrier effect of membranes on cellular or tissue level, pathophysiological drug resistance mechanisms by the cells, and biodistribution behaviour of the drug. At the tumor level, the drug transport being governed also by the physicochemical properties of the interstitium (composition, structure, charge) and of the molecule properties (size, configuration, charge, hydrophobicity) [Jain, 2007].