ABSTRACT
Polymorphonuclear leukocytes (PMN) have so far rarely been associated with atherosclerosis and its complications. Just now, studies are evolving that highlight mechanisms by which PMN control inflammatory process in atherosclerosis. Due to the restricted knowledge on the impact of PMN in atherosclerosis lesion formation, progression, and rupture, little therapeutic strategies specifically targeting the PMN have been developed. Hence, we here describe mechanisms by which PMN might promote atherosclerotic lesion formation. Potential targets detailed here, primarily derive from microvascular studies.
