ABSTRACT
In the human body the vascular network links organs, which,
besides transporting oxygen and nutrients, is a vital communication
highway for metabolic signaling between tissues. Unraveling the
complexity of interorgan and intertissue cross talk in vivo is a
complex and challenging task. Intelligent in vitro models able to
recapitulate the physiological interactions between tissues in the
body connected by the bloodstreamhave enormous potential as they
enable detailed studies on specific two-way or higher-order organ-
organ and tissue interactions. An integrated systemic view can thus
be constructed piecewise. The aim of this paper is to show how
allometry can be used to set up physiologically relevant connected
culture models of biotransformation, distribution, adsorption and
gas exchange in the Quasi-Vivo R© system.
