ABSTRACT
The evaluation of in vivo or ex vivo biodistribution of NPs can be addressed using several different approaches. Non-invasive radioactive molecular imaging techniques, such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET), enable absolute PK quantification in preclinical and human subjects [11-18]. Application of these imaging methods to NP biodistribution studies provides sensitive and quantitative in vivo measurements that can serve as the basis to fully explore their utility as therapeutic or diagnostic agents.
