Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now.

A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills.

This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

chapter Chapter 1|7 pages


ByGary Evans

chapter Chapter 2|24 pages

The importance of the physicochemical properties of drugs to drug metabolism

ByDavid Spalding

chapter Chapter 3|13 pages

Sample preparation

ByBob Biddlecombe, Glenn Smith

chapter |24 pages

High-performance liquid chromatography in pharmaceutical bioanalysis

ByDavid N. Mallett

chapter Chapter 5|21 pages

Mass spectrometry and quantitative bioanalysis

ByBob Biddlecombe, Sheryl Callejas, Gary Evans

chapter Chapter 6|23 pages

Immunoassay in pharmacokinetic and pharmacodynamic bioanalysis

ByRichard Nicholl, Paul Linacre, Bill Jenner

chapter Chapter 7|19 pages

Pre-clinical pharmacokinetics

BySheila Schwartz, Tony Pateman

chapter Chapter 8|10 pages

Pharmacokinetic/pharmacodynamic modelling in pre-clinical drug discovery

ByTony Pateman

chapter Chapter 9|14 pages


BySheila Schwartz

chapter Chapter 10|20 pages

Protein binding in plasma: a case history of a highly protein-bound drug

ByRobert J. Barnaby, Marco Bottacini

chapter Chapter 11|15 pages

Isotope drug studies in man

ByGraeme Young, John Ayrton, Tony Pateman

chapter Chapter 12|17 pages

Whole body autoradiography

ByLee Crossman, Kenneth Brouwer, Jeanne Jarrett

chapter Chapter 13|14 pages

Phase I metabolism

ByPeter Eddershaw, Maurice Dickins

chapter Chapter 14|22 pages

Phase II enzymes

ByGary Manchee, Maurice Dickins, Elizabeth Pickup

chapter Chapter 15|25 pages

In vitro techniques for investigating drug metabolism

ByGraham Somers, Peter Mutch, Amanda Woodrooffe

chapter Chapter 16|23 pages

Drug–drug interactions: an in vitro approach

ByD.M. Cross, M.K. Bayliss

chapter Chapter 18|34 pages

Molecular biology

BySteve Hood