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Book

Chromosomal Instability and Aging

Book

Chromosomal Instability and Aging

DOI link for Chromosomal Instability and Aging

Chromosomal Instability and Aging book

Basic Science and Clinical Implications

Chromosomal Instability and Aging

DOI link for Chromosomal Instability and Aging

Chromosomal Instability and Aging book

Basic Science and Clinical Implications
ByFuki Hisama, Sherman M. Weissman, George M. Martin
Edition 1st Edition
First Published 2003
eBook Published 12 March 2003
Pub. Location Boca Raton
Imprint CRC Press
DOI https://doi.org/10.1201/9780203911709
Pages 600
eBook ISBN 9780429213779
Subjects Medicine, Dentistry, Nursing & Allied Health
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Hisama, F., Weissman, S.M., & Martin, G.M. (2003). Chromosomal Instability and Aging: Basic Science and Clinical Implications (1st ed.). CRC Press. https://doi.org/10.1201/9780203911709

ABSTRACT

This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, includ

TABLE OF CONTENTS

chapter 1|8 pages

Introduction

ByGeorge M. Martin

chapter 2|20 pages

Overview of Chromosomal Instability and Aging Mechanisms

ByFuki M. Hisama, Poornima K. Tekumalla, Sherman M. Weissman

chapter 3|22 pages

Cellular Senescence

ByJudith Campisi

chapter 4|22 pages

Telomeric Shortening and Replicative Aging

ByWoodring E. Wright, Jerry W. Shay

chapter 5|34 pages

Telomeric Regulation in Eukaryotic Cells

ByRachel M. Stansel, Jack D. Griffith

chapter 6|18 pages

Role of Ku at the Telomere

ByDavid Gilley, David J. Chen

chapter 7|24 pages

Chromosomal Instability in Normative Aging

ByBirgit Maurer, Martina Guttenbach, Michael Schmid

chapter 8|18 pages

Chromatin, Aging, and Cellular Senescence

ByBruce H. Howard

chapter 9|20 pages

Werner Syndrome

ByJunko Oshima

chapter 10|36 pages

.Bloom Syndrome: Genetic, Cellular, and Molecular Features as Compared to Werner Syndrome

ByPeng Hu, Nathan A. Ellis

chapter 11|22 pages

Molecular Biology of Rothmund–Thomson Syndrome

BySaori Kitao, Akira Shimamoto, Yasuhiro Furuichi

chapter 12|18 pages

Hutchinson–Gilford Progeria Syndrome

ByW. Ted Brown

chapter 13|48 pages

Ataxia-Telangiectasia

ByM. Stephen Meyn

chapter 14|34 pages

Nijmegen Breakage Syndrome

ByEberhard Fritz, Martin Digweed

chapter 15|30 pages

Dyskeratosis Congenita

ByNina S. Heiss, Annemarie Poustka

chapter 16|34 pages

Genetic Instability and Fanconi Anemia

ByHolger Hoehn, Michaela Thiel Gross, Alexandra Sobeck, Matthias Wagner, Detlev Schindler

chapter 17|32 pages

Xeroderma Pigmentosum

ByMaria I. Fousteri, Alan R. Lehmann

chapter 18|24 pages

Down Syndrome

ByLeslie Colvin, Stania B. Jurenka, Margot I. Van Allen

chapter 19|28 pages

Genomic Instability and Yeast Aging

ByRobert A. Marciniak

chapter 20|16 pages

Genetics of Aging in the Nematode Caenorhabditis elegans

ByPhilip S. Hartman, Naoaki Ishii, Thomas E. Johnson

chapter 21|14 pages

Aging, Somatic Maintenance, and Genomic Stability in Drosophila melanogaster

ByJohn Tower

chapter 22|24 pages

Telomerase-Deficient Mouse Model

ByEnrique Samper, María A. Blasco

chapter 23|18 pages

Animal Models of Oxidative Stress and Aging

ByDoug Hinerfeld, Simon Melov

chapter 24|10 pages

Conclusions and Future Directions

ByFuki M. Hisama, Sherman M. Weissman, George M. Martin
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