Paracrine and autocrine regulation of cardiac function by "endothelial" mediators is becoming important both physiologically and pathophysiologically. This volume brings the researcher completely up to date with all aspects of endothelial regulation and cardiac function. Acknowledged experts in each field have contributed, making this work indispensable for researchers and of great interest to the clinical cardiologist.
The Endothelial Cell Research Series publishes significant reviews by experts in the field. The individual volumes provide invaluable guides to researchers studying endothelial cells and are effective reference texts for anyone working in the general areas of vascular biology and neurotransmission.
Endothelium was originally considered to be an inert lining for the blood vessels, but during the last fifteen years, this view has had to be completely revised. It is now accepted that the endothelium plays an important role in many diverse functions. This volume concentrates on the effect of the endothelium on cardiac function. It has been widely demonstrated that the endothelium exerts a paracrine influence on contraction of adjacent cardiac muscle through the release of several mediators, such as endothelin and nitric oxide. Recent studies also show that the effects of such mediators upon the heart are not limited to contraction alone.

chapter 1|18 pages

Endocardial Endothelial Modulation of Myocardial Contraction

ByStanislas U. Sys, Puneet Mohan, Luc J. Andries, Gilles De Keulenaer, Paul F. Fransen, Dirk L. Brutsaert

chapter 2|16 pages

Nitric Oxide and Myocardial Contraction: Experimental Studies

ByRichard M. Grocott-Mason, Peter B. Anning, Malcolm J. Lewis, Ajay M. Shah

chapter 3|17 pages

Nitric Oxide and Cardiac Contraction: Clinical Studies

ByWalter J. Paulus

chapter 4|18 pages

Molecular Regulation of NO Synthase in the Heart

ByJean-Luc Balligand, Thomas W. Smith

chapter 5|20 pages

Nitric Oxide, Sepsis and the Heart

ByLouis H. Alarcon, Timothy R. Billiar, Richard L. Simmons

chapter 7|10 pages

Can Nitric Oxide Influence Ischaemia/Reperfusion Injury?

ByK.-D. Schlüter, G. Kojda, H.M. Piper

chapter 8|12 pages

Endothelin and Cardiac Contraction

ByDavid T. Huang, James P. Morgan

chapter 9|14 pages

Endothelin Receptor-Effector Coupling and Signaling in Cardiac Cells

ByLaurence L. Brunton

chapter 10|17 pages

Endothelin and Cardiac Hypertrophy

ByHiroshi Ito

chapter 11|10 pages

Endothelium and Myocardial Growth and Fibrosis

ByAlexandre Mebazaa, Stefano Corda, Lydie Rappaport, Jane-Lyse Samuel

chapter 13|19 pages

Endothelial Regulation of Cardiac Myofilament Responsiveness to Calcium

ByChris B. Pepper, Alexandre Mebazaa, Bernard D. Prendergast, Zhao-Kang Yang, Nick J. Draper, Vadim Sagach, Ajay M. Shah

chapter 14|17 pages

Natriuretic Peptides and Cardiac Function

ByKazuhiro Yamamoto, Margaret M. Redfield, John C. Burnett

chapter 15|13 pages

Cardiac Inhibition of Angiotensin Converting Enzyme: Role of Kinins

ByWolfgang Linz, Gabriele Wiemer, Bernward A. Schölkens

chapter 16|18 pages

Coronary Vascular Endothelium, Preconditioning and Arrhythmogenesis

ByJames R. Parratt, Agnes Vegh