Learning from Disease in Pets: A ‘One Health’ Model for Discovery is the first encompassing reference guide for veterinarians, researchers and physicians on conducting studies using spontaneous models of disease in animals. The study of naturally occurring disease in (pet) animals can help model our understanding of the biology, prevention and therapy of human and animal diseases. Studies of pet dogs, for instance, can aid treatment of complex medical problems such as cancer, orthopedic, cardiopulmonary, and neuro-inflammatory diseases, and zoonotic infections. Each chapter within this novel cross-species approach is contributed by a leader, or leaders, in their field of research.

Using clinical trials to learn how pets with real diseases respond to therapy can lead to breakthroughs in human medicine, as well as benefiting pets suffering from otherwise debilitating illness. Despite similarities of diseases across species, there are very few spontaneous models of disease used in research compared with models where disease is induced in healthy laboratory animals. Many medical researchers and veterinarians have a multitude of questions regarding how to use naturally occurring diseases in pets for the discovery of treatments and diagnostics: this book will demonstrate how to safely make this happen.

This book encourages veterinarians to build on and disseminate existing findings for the wider benefit of pets and humans. Many pets suffering from incurable illnesses may benefit from clinical trials; the book includes a section on the imperative communication styles necessary within the research environment and with clients, a compelling discussion on the ethics of using pets in veterinary clinical research, comprehensive tables of diseases that spontaneously occur in animals and humans, the regulatory requirements necessary to move therapy from benchside research to patient bedside, as well as intricate details on how to design a robust clinical study.



chapter 1|12 pages

The Contribution of Pets to Human and Veterinary Medicine

ByRebecca A. Krimins

chapter 2|58 pages

Companion Animals Models of Human Disease

ByDavid Bruyette

chapter 3|30 pages

Specific Diseases of Large Animals and Man

ByTimothy Lescun

chapter 4|12 pages

Cancer Research Is Leading the Way

ByDiane Peters

chapter 5|18 pages

Investment Dynamics in the World of Pharma

ByBryan Jones

chapter 6|16 pages

How to Perform Research in Spontaneous Models of Disease

ByKristen V. Khanna, Philippe Brianceau

chapter 7|12 pages

The Use of Animals in Research

ByVictoria K. Baxter

chapter 8|20 pages

DNA Methods in Veterinary Medicine

ByAlan F. Scott

chapter 9|6 pages

The Importance of Collecting Tissue from Pets (Alive and Deceased)

ByRebecca A. Krimins

chapter 10|24 pages

The FDA New Animal Drug Approval Process

ByJacob Michael Froehlich, Alice Ignaszewski, Anna O’Brien

chapter 11|16 pages

Clinical Trials, Patient Recruitment and Advertising

ByKrista K. Vermillion

chapter 12|26 pages

One Health

Animals, Humans, and Our Planet
ByRadford G. Davis

chapter 13|10 pages

Communication and Expectations

ByKristen V. Khanna, Karen Gozdan-Aiken

chapter 14|14 pages

Ethical Considerations

BySteven M. Niemi