ABSTRACT

This handbook provides a unique overview of lipid membrane fundamentals and applications. The fascinating world of lipids that harbor and govern so many biological functionalities are discussed within the context of membrane structures, interactions, and shape evolution. Beyond the fundamentals in lipid science, this handbook focuses on how scientists are building bioinspired biomimetic systems for applications in medicine, cosmetics, and nanotechnology.

Key Features:

  • Includes experimental and theoretical overviews on the role of lipids, with or without associated biomolecules, as structural components imparting distinct membrane shapes and intermembrane interactions
  • Covers the mechanisms of lipid-membrane curvature, by peptide and protein binding, and the roles of signalling lipids and the cytoskeleton in plasma membrane shape evolution
  • Covers advanced X-ray and force measurement techniques
  • Discusses applications in biomedicine, cosmetics, and nanotechnology, including lipid vectors in nucleic acid, drug delivery in dermal applications, and lipid-based sensors and artificial biointerfaces
  • Covers artificial membranes from block copolymers, synthetic copolypeptides, and recombinant proteins
  • Includes an exciting section that explores the role of lipids in the origin of life in hydrothermal conditions

This book is a highly informative companion for professionals in biophysics, biochemistry, physical chemistry, and material and pharmaceutical sciences and bioengineering.

chapter 1|31 pages

A Short History of Membrane Physics

ByErich Sackmann, Avinoam Ben-Shaul

chapter 3|15 pages

Structures of Lipid Membranes: Cubic and Inverse Hexagonal Phases

ByCharlotte E. Conn, John M. Seddon

chapter 6|30 pages

Charged Membranes: Poisson–Boltzmann Theory, The DLVO Paradigm, and Beyond

ByTomer Markovich, David Andelman, Rudolf Podgornik

chapter 7|11 pages

Membrane Shape Evolution In Vitro

ByAlexandra Zidovska

chapter 8|19 pages

Mechanisms of Membrane Curvature Generation by Peptides and Proteins: A Unified Perspective on Antimicrobial Peptides

ByMichelle W. Lee, Nathan W. Schmidt, Gerard C. L. Wong

chapter 9|15 pages

Lipid Membrane Shape Evolution and the Actin Cytoskeleton

ByDavid R. Slochower, Yu-Hsiu Wang, Ravi Radhakrishnan, Paul A. Janmey

chapter 10|18 pages

Effects of Osmotic Stress on Topologically Closed Membrane Compartments

ByJames C. S. Ho, Bo Liedberg, Atul N. Parikh

chapter 12|12 pages

Lipids in DNA, RNA, and Peptide Delivery for In Vivo Therapeutic Applications

ByTyler Goodwin, Leaf Huang

chapter 13|18 pages

Electrostatics of Lipid Membranes Interacting with Oppositely Charged Macromolecules

ByGuilherme Volpe Bossa, Klemen Bohinc, Sylvio May

chapter 14|29 pages

Lipid-Based Bioanalytical Sensors

ByMarta Bally, Hudson Pace, Fredrik Höök

chapter 15|21 pages

Lipids in Dermal Applications: Cosmetics and Pharmaceutics

ByJérôme Bibette, Abdou Rachid Thiam

chapter 16|12 pages

Supported Lipid Bilayers

ByTheo Lohmüller, Bert Nickel, Joachim O. Rädler

chapter 17|17 pages

Artificial Membranes Composed of Synthetic Copolypeptides

ByTimothy J. Deming

chapter 18|14 pages

Synthetic Membranes from Block Copolymers, Recombinant Proteins, and Dendrimers

ByDaniel A. Hammer, Zhichun Wang, Ellen Reed, Chen Gao, Kevin B. Vargo

chapter 19|12 pages

Amphiphilic Self-Assembly and the Origin of Life in Hydrothermal Conditions

ByChristos D. Georgiou, David W. Deamer