This new edition provides the essential clinical guidance both for those embarking upon a career in palliative medicine and for those already established in the field. A team of international experts here distil what every practitioner needs to know into a practical and reliable resource.

chapter 1|6 pages

The Development of Hospice and Palliative Care

ByKate Kirk

chapter 2|10 pages

Palliative Care as a Public Health Issue

ByIrene J. Higginson, Massimo Costantini

chapter 3|8 pages

Palliative Care as a Primary Care Issue

ByScott A. Murray, Sebastien Moine, Kirsty Boyd

chapter 4|8 pages

The Future of Palliative Medicine

ByCharles F. von Gunten, Irene J. Higginson

chapter 5|6 pages

Palliative Care and Supportive Care

ByEduardo Bruera

chapter 6|8 pages

Ethics in the Practice of Palliative Care

ByNelia Jain, James A. Tulsky

chapter 7|4 pages

Undergraduate Education in Palliative Medicine

ByLinh My Thi Nguyen

chapter 8|10 pages

Graduate Education for Nonspecialists

ByFiona Rawlinson, Ilora G. Finlay

chapter 9|10 pages

Challenges of Research in Palliative and Supportive Medicine

ByIrene J. Higginson

chapter 10|6 pages

The Population: Who are the Subjects in Palliative Medicine Research?

ByClaudia Bausewein, Fliss E.M. Murtagh

chapter 11|8 pages

Study Designs in Palliative Medicine

ByMassimo Costantini

chapter 12|10 pages

Outcome Measurement in Palliative Care

ByJoan M. Teno

chapter 13|12 pages

Ethics in Palliative Care Research

ByJonathan Koffman, Emel Yorganci

chapter 14|8 pages

Adoption of Palliative Care: The Engineering of Organizational Change

ByWinford E. (Dutch) Holland, Eduardo Bruera

chapter 15|4 pages

Principles of Measuring the Financial Outcomes of Specialist Palliative Care Programs

ByJ. Brian Cassel, Thomas J. Smith

chapter 16|8 pages

Population-Based Needs Assessment for Patients and those Important to them, Such as Families

ByIrene J. Higginson, Richard Harding

chapter 17|10 pages

Models of Palliative Care Delivery

ByEduardo Bruera, Jessica H. Brown

chapter 18|6 pages

Home Palliative Care

ByHeather Grant, Dana Lustbader

chapter 19|6 pages

Palliative Care Unit

ByKaren Macmillan, Kelley Fournier, Beth Tupala, Kim Crowe Mackinnon

chapter 20|18 pages

Multidimensional Patient Assessment

ByMarvin Omar Delgado-Guay, Alexander Harding

chapter 21|22 pages

Tools For Pain and Symptom Assessment

ByVictor T. Chang

chapter 22|10 pages

Quality of Life Assessment in Palliative Care

ByRichard Sawatzky, S. Robin Cohen

chapter 23|8 pages

Pathophysiology of Chronic Pain

BySebastiano Mercadante

chapter 24|14 pages

Causes and Mechanisms of Pain in Palliative Care Patients

ByMichal Kubiak, Marieberta Vidal, Suresh K. Reddy

chapter 25|14 pages

Opioid Analgesics

ByGeana Paula Kurita, Stein Kaasa, Per Sjøgren

chapter 26|14 pages

Assessment and Management of Opioid Side Effects

ByShalini Dalal

chapter 27|6 pages

Adjuvant Analgesic Medications

ByJessica Geiger

chapter 28|16 pages

Alternative Routes for Systemic Opioid Delivery

ByRaffaele Giusti, Monica Bosco, Maurizio Lucchesi, Carla Ida Ripamonti

chapter 29|14 pages

Interventional Pain Procedures in Palliative Care

ByPo-Yi Paul Su, Ann Cai Shah, Sarah Gebauer

chapter 30|8 pages

Pain Management in Pediatrics

ByKevin Madden

chapter 31|8 pages

Pain in the Older Adult

ByLinh My Thi Nguyen, Michelle Peck

chapter 32|12 pages

Neuropathic Pain

ByPaolo Marchettini, Fabio Formaglio, Marco Lacerenza

chapter 33|10 pages

Bone Cancer Pain and Skeletal Complications

ByYoko Tarumi

chapter 34|10 pages

Breakthrough (Episodic) Pain in Cancer Patients

ByShirley H. Bush

chapter 35|4 pages

Somatic Symptoms, Symptom Clusters, and Symptom Burden

ByDavid V. Nelson, Diane M. Novy

chapter 36|6 pages

Pain in Patients with Alcohol and Drug Dependence

ByLeah Couture, Malisa Dang, Danielle Noreika

chapter 37|14 pages

Cachexia–Anorexia Syndrome

ByPaul Zelensky, Mallika Dammalapati, Egidio Del Fabbro

chapter 38|8 pages


BySebastiano Mercadante

chapter 39|10 pages


ByCharu Agrawal, Karina Shih

chapter 40|6 pages


ByNathan I. Cherny

chapter 41|14 pages

Malignant Bowel Obstruction

ByCarla I. Ripamonti, Alexandra M. Easson, Hans Gerdesh

chapter 42|6 pages

Endoscopic Treatment of Digestive Symptoms

ByPasquale Spinelli

chapter 43|20 pages

Mechanism, Assessment, and Management of Fatigue

BySean Hutchinson, Sriram Yennurajalingam

chapter 44|12 pages


ByClaudia Bausewein, Sara Booth

chapter 45|8 pages

Other Respiratory Symptoms (Cough, Hiccup, and Secretions)

ByRegina M. Mackey, Francisco Loaiciga

chapter 46|14 pages


ByTatsuo Akechi

chapter 47|12 pages


ByYesne Alici, William S. Breitbart

chapter 48|10 pages

Sleep Disturbances in Advanced Cancer Patients

ByDelmer A. Montoya, Sriram Yennurajalingam

chapter 49|8 pages

Counseling in Palliative Care

BySophie A. McGilvray, David W. Kissane

chapter 50|8 pages

Hope in End-of-Life Care

ByCheryl L. Nekolaichuk

chapter 51|8 pages

Dehydration and Rehydration

ByRobin L. Fainsinger

chapter 52|14 pages

Fever, Sweats, and Hot Flashes

ByAhsan Azhar, Shalini Dalal

chapter 53|10 pages


ByMichael Tang, Katie Taylor, Andrew Thorns

chapter 54|6 pages

Infections in Palliative Care

ByRudolph M. Navari

chapter 55|8 pages

Pediatric Palliative Wound Care: The Unique Anatomy and Physiology of Neonatal Skin

ByAnn Marie Nie, Joyce M. Black

chapter 56|8 pages

Mouth Care

ByFlavio Fusco

chapter 57|6 pages


ByMaurizio Lucchesi, Fabio Fulfaro, Raffaele Giusti, Carla Ida Ripamonti

chapter 58|10 pages

Assessment and Management of Lymphedema

ByYing Guo, Mark V. Schaverien

chapter 59|6 pages


ByKimberson Tanco, Saima Rashid

chapter 60|10 pages


ByTimothy Fuller, Kencee Graves, Jen-Yu Wei

chapter 61|8 pages

Spinal Cord Compression

ByMaitry Patel, Adrian Cozma, Edward Chow, Srinivas Raman

chapter 62|6 pages

Clinical Features and Management of Superior Vena Cava Syndrome

ByÁlvaro Sanz, María Luisa del Valle, Carlos Centeno

chapter 63|20 pages

Acute Pain and Management

ByMellar P. Davis

chapter 64|10 pages


ByDaniel C. McFarland, Yesne Alici, William S. Breitbart

chapter 65|16 pages

Cancer: Radiotherapy

ByAdrian Cozma, Maitry Patel, Edward Chow, Srinivas Raman

chapter 67|6 pages

Integrative Medicine in Supportive and Palliative Care

ByGabriel Lopez, Santhosshi Narayanan, Wenli Liu, Lorenzo Cohen

chapter 68|8 pages

Neurological Diseases

ByTobias Walbert, Joel Phillips

chapter 69|6 pages

End-Stage Congestive Heart Failure

BySam Straw, Klaus K. Witte, Mark T. Kearney

chapter 70|8 pages

Geriatric Palliative Care

ByKimberson Tanco, Maxine De La Cruz

chapter 71|10 pages

Advanced Chronic Obstructive Pulmonary Disease

ByDaisy J.A. Janssen, Lynn F. Reinke, J. Randall Curtis

chapter 72|10 pages

Other Infectious Diseases: Malaria, Rabies, Tuberculosis

ByRichard Harding, Rene Krause, Sue Marsden

chapter 74|12 pages

Prognostic Indicators of Survival

ByMorena Shkodra, Augusto T. Caraceni, Marco Maltoni, Caterina Modonesi

chapter 75|10 pages

Palliative Sedation

ByNathan I. Cherny

chapter 76|8 pages

Staff Stress and Burnout in Palliative Care

ByAimee E. Anderson, Eduardo Bruera

chapter 77|8 pages

Spiritual Care

ByMarvin Omar Delgado- Guay, Alexander Harding

chapter 78|18 pages

Family Caregivers and Cultural Sensitivity

ByRony Dev, Ali Haider

chapter 79|8 pages


ByVictoria H. Raveis

chapter 80|8 pages

Children of Palliative Care Patients

ByEstela Beale, Sujin Ann-Yi

chapter 81|6 pages

Neutropenic Fever

ByHiroshi Ishiguro, Harumi Gomi

chapter 82|8 pages

Side Effects of Radiation Therapy

ByMichael Wang, Elizabeth A. Barnes

chapter 83|4 pages

Cardiac and Pulmonary Toxicities of Treatments

ByMarieberta Vidal

chapter 84|8 pages

Oral Complications of Cancer Therapies

BySiri Beier Jensen, Deborah P. Saunders

chapter 85|8 pages

Dermatologic Side Effects

ByJen-Yu Wei, Michael Goodblatt

chapter 86|8 pages

Peripheral Neuropathy and Neurotoxicity

BySheetal Shroff, Akhil Shivaprasad, Ivo W. Tremont-Lukats

chapter 87|6 pages

Sex and Sexuality

ByMary K. Hughes

chapter 88|6 pages

Managing Communication Challenges with Patients and Families

ByAnthony L. Back

chapter 89|10 pages

Supportive and Palliative Care for Patients with HIV Infection

ByRichard Harding, Elizabeth J. Chuang, Peter A. Selwyn

chapter 90|20 pages

Implantable Cardiac Devices

ByLaura J. Morrison

chapter 91|12 pages

Supportive Care for Patients with Advanced Chronic Kidney Disease

BySara N. Davison

chapter 92|6 pages

Palliative Care in the Emergency Department

ByTravis DeVader, Tammie Quest

chapter 93|18 pages

Optimal Symptom Management in Hematopoietic Stem Cell Transplantation

ByKatie N. Kanter, Allison Kestenbaum, Thomas W. LeBlanc, Eric J. Roeland, N Kanter Katie, Kestenbaum Allison, W LeBlanc Thomas

chapter 94|12 pages

The End of Therapy: Building the Psychosocial and Spiritual Bridges to Survivorship

ByMarvin Omar Delgado-Guay, Paige Farinholt

chapter 95|4 pages

Rehabilitation in the Acute and Chronic Care Setting

ByGeorge J. Francis, Ki Y. Shin

chapter 96|6 pages

Long-Term Cognitive Function

ByAsao Ogawa

chapter 97|6 pages

Gonadal Functions and Reproductive Health

ByKoji Kawai, Miyuki Harada, Yutaka Osuga, Hiroyuki Nishiyama

chapter 98|4 pages

Pulmonary Rehabilitation

ByRyo Kozu