This fully revised edition of Handbook of Pharmaceutical Granulation Technology covers the rapid advances in the science of agglomeration,  process control, process modelling, scale-up, emerging particle engineering technologies, along with current regulatory changes presented by some of the prominent scientist and subject matter experts around the globe. Learn from more than 50 global subject matter experts who share their years of experience in areas ranging from drug delivery and pharmaceutical technology to advances in nanotechnology. Every pharmaceutical scientist should own a copy of this fourth edition resource.

Key Features:

  • Theoretical discussions covering granulation and engineering perspectives.
  • Covers new advances in expert systems, process modelling and bioavailability
  • Chapters on emerging technologies in particle engineering
  • Updated Current research and developments in granulation technologies

chapter 1|7 pages


ByDilip M. Parikh

chapter 2|58 pages

Theory of Granulation

An Engineering Perspective
ByBryan J. Ennis, Michael Winn, Brandon Ennis, Naseem Jibrin

part Section I|177 pages

Particle Formation

chapter 3|34 pages

Drug Substance and Excipient Characterization

ByParind M. Desai, Lai Wah Chan, Paul Wan Sia Heng

chapter 4|31 pages

Binders in Pharmaceutical Granulation

ByThomas Dürig, Kapish Karan

chapter 5|26 pages

Excipients and Their Attributes in Granulation

ByAnthony E. Carpanzano

chapter 6|57 pages

Spray Drying and Pharmaceutical Applications

ByMetin Çelik, Pavan Muttil, Gülşilan Binzet, Susan C. Wendell

chapter 7|25 pages

Emerging Technologies for Particle Engineering

ByDilip M. Parikh

part Section II|221 pages

Granulation Processes

chapter 8|35 pages

Roller Compaction Technology

ByRonald W. Miller, Vishwas Nesarikar

chapter 9|24 pages

Advances in Wet Granulation of Modern Drugs

ByBing Xun Tan, Wen Chin Foo, Keat Theng Chow, Rajeev Gokhale

chapter 10|76 pages

Fluid Bed Processing

ByDilip M. Parikh

chapter 11|25 pages

Single-Pot Processing

ByGriet Van Vaerenbergh, Harald Stahl

chapter 12|35 pages

Extrusion/Spheronization as a Granulation Technique

ByDavid F. Erkoboni

chapter 13|21 pages

Continuous Granulation

ByChris Vervaet, Thomas De Beer, Valérie Vanhoorne

part Section III|126 pages

Product-Oriented Granulations

chapter 14|18 pages

Effervescent Granulation

ByGuia Bertuzzi

chapter 15|16 pages

Granulation of Plant Products and Nutraceuticals

ByDilip M. Parikh

chapter 16|21 pages

Granulation Approaches for Modified-Release Products

ByNeelima Phadnis, Sree Nadkarni

chapter 17|29 pages

Granulation of Poorly Water-Soluble Drugs

ByAlbert W. Brzeczko, Firas El Saleh, Hibreniguss Terefe

chapter 18|20 pages

Granulation and Production Approaches of Orally Disintegrating Tablets

ByTansel Comoglu, Fatemeh Bahadori

chapter 19|18 pages

Melt Granulation

ByShana Van de Steene, Valérie Vanhoorne, Chris Vervaet, Thomas De Beer

part Section IV|170 pages

Characterization and Scale-UP

chapter 20|23 pages

Sizing of Granulation

ByGurvinder Singh Rekhi, Richard Sidwell

chapter 21|22 pages

Granulation Characterization

ByCecil W. Propst

chapter 22|16 pages

Bioavailability and Granule Properties

BySunil S. Jambhekar

chapter 23|48 pages

Granulation Process Modeling

ByIan T. Cameron, Fu Y. Wang

chapter 24|39 pages

Scale-Up Considerations in Granulation

ByYinghe He, Lian X. Liu, James Litster, Defne Kayrak-Talay

chapter 25|18 pages

Advances in Process Controls and End-Point Determination

ByKevin A. Macias, M. Teresa Carvajal

part Section V|104 pages

Optimization Strategies,Tools, and Regulatory Considerations

chapter 27|26 pages

Regulatory Issues in Granulation

Leading Next-Generation Manufacturing
ByPrasad Kanneganti

chapter 28|40 pages

QbD and PAT in Granulation

ByShivang Chaudhary