Intravoxel incoherent motion (IVIM) refers to translational movements which within a given voxel and during the measurement time present a distribution of speeds in orientation and/or amplitude. The concept was introduced in 1986 together with the foundation of diffusion MRI because it had been realized that flow of blood in capillaries (perfusion) would mimic a diffusion process and impact diffusion MRI measurements. IVIM-based perfusion MRI, which does not require injection of any tracer or contrast agent, has been first investigated in the brain, but is now experiencing a remarkable revival for applications throughout the body, especially for oncologic applications, from diagnosis to treatment monitoring. 

This book addresses a number of highly topical aspects of the field from leading authorities, introducing the concepts behind IVIM MRI, outlining related methodological issues, and summarizing its current usage and potential for clinical applications. It also presents future research directions, both in terms of methodological development and clinical application fields, extending to new, non-perfusion applications of IVIM MRI, such as virtual MR elastography.

part 1|2 pages

Section I Introduction to IVIM MRI

chapter 1|27 pages

Introduction to IVIM MRI

ByDenis Le Bihan

part 2|2 pages

Section II Other MRI Approaches to Perfusion Imaging

chapter 2|36 pages

Other MRI Approaches to Perfusion Imaging (ASL, DSC, DCE)

ByEmmanuel L. Barbier, Sylvie Grand, Alexandre Krainik, Jan M. Warnking

part 3|2 pages

Section III Clinical Applications of IVIM MRI Part 1: Neurological Applications

chapter 3|16 pages

Clinical Applications of IVIM MRI to the Nervous System

ByC. Federau

chapter 4|14 pages

IVIM MRI: A Window to the Pathophysiology Underlying Cerebral Small Vessel Disease

ByJacobus F. A. Jansen, Sau May Wong, Walter H. Backes

chapter 5|16 pages

IVIM fMRI: Brain Activation with a High Spatial Specificity and Resolution

ByAllen W. Song, Iain Bruce, Christopher Petty, Nan-Kuei Chen

part 4|2 pages

Section III Clinical Applications of IVIM MRI Part 2: Body IVIM MRI

chapter 6|30 pages

IVIM in the Body: A General Overview

ByMatthew R. Orton, Neil P. Jerome, Mihaela Rata, Dow-Mu Koh

chapter 7|26 pages

Head and Neck IVIM MRI

ByTakashi Nakamura, Misa Sumi

chapter 8|22 pages

IVIM MRI of the Breast

ByMami Iima, Masako Kataoka

chapter 9|10 pages

Cardiac IVIM MRI

ByZhiyong Li, Anna Mou

chapter 10|14 pages

Liver Fibrosis

ByShintaro Ichikawa, Utaroh Motosugi

chapter 11|26 pages

Assessment of Liver Tumors with IVIM Diffusion-Weighted Imaging

ByStefanie J. Hectors, Sara Lewis, Bachir Taouli

chapter 12|16 pages

IVIM MRI of the Pancreas

ByMiriam Klauß, Philipp Mayer, Bram Stieltjes

chapter 13|22 pages

IVIM MRI in the Kidney

ByMoritz J. Schneider, Mike Notohamiprodjo, Olaf Dietrich

chapter 14|8 pages

IVIM Diffusion Model in Prostate Cancer

ByBaris Turkbey, Stephanie Harmon, Marcin Czarniecki, Peter L. Choyke

chapter 15|26 pages

Clinical Application of IVIM in the Female Pelvis

ByElaine Y. P. Lee, Pek-Lan Khong

chapter 16|22 pages

IVIM MRI of the Placenta

ByPaddy J. Slator, Jana Hutter, Eleftheria Panagiotaki, Mary A. Rutherford, Joseph V. Hajnal, Daniel C. Alexander

chapter 17|20 pages


ByAndrás Jakab, Raimund Kottke, Ianina Scheer, Ruth Tuura

chapter 18|14 pages

IVIM MRI and Bone Marrow

ByRobert Burns, Sébastien Mulé, Pierre Zerbib, Alexandre Vignaud, Emmanuel Itti, Alain Rahmouni, Alain Luciani

part 5|2 pages

Section IV Next Frontiers of IVIM MRI

chapter 19|28 pages

IVIM Models: Advantages, Disadvantages, and Analysis Pitfalls

ByGabrielle Fournet, Luisa Ciobanu, Denis Le Bihan

chapter 21|12 pages

Flow Compensation and Modeling of IVIM MRI in the Liver and Pancreas

ByAndreas Wetscherek

chapter 22|14 pages

Perfusion Marries Diffusion: Arterial Spin Labeling Prepared IVIM

ByXingxing Zhang, Matthias J. P. van Osch

chapter 23|36 pages

Advanced Methods for IVIM Parameter Estimation

ByPeter T. While

chapter 24|22 pages

IVIM MRI Analysis with Low Perfusion

ByEmma M. Meeus, Andrew C. Peet

chapter 25|18 pages

Synthetic and Physiological IVIM Complexity

ByEric E. Sigmund