Based on the success of the first edition, this second edition continues to build upon fundamental principles of biosensor design and incorporates recent advances in intelligent materials and novel fabrication techniques for a broad range of real world applications. The book provides a multi-disciplinary focus to capture the ever-expanding field of biosensors.

Smart Biosensor Technology, Second Edition includes contributions from leading specialists in a wide variety of fields with a common focus on smart biosensor design. With 21 chapters organized in five parts, this compendium covers the fundamentals of smart biosensor technology, important issues related to material design and selection, principles of biosensor design and fabrication, advances in bioelectronics, and a look at specific applications related to pathogen detection, toxicity monitoring, microfluidics and healthcare.


  • Provides a solid background in the underlying principles of biosensor design and breakthrough technologies for creating more intelligent biosensors
  • Focusses on material design and selection including cutting-edge developments in carbon nanotubes, polymer nanowires, and porous silicon
  • Examines machine learning and introduces concepts such as DNA-based molecular computing for smart biosensor function
  • Explores the principles of bioelectronics and nerve cell microelectrode arrays for creating novel transducers and physiological biosensors
  • Devotes several chapters to biosensors developed to detect and monitor a variety of toxins and pathogens
  • Offers expert opinions on the future directions, challenges and opportunities in the field

section Section I|1 pages

Overview and Fundamentals

chapter 1|25 pages

Introduction to Biosensors and Bioelectronics

ByGeorge K. Knopf, Amarjeet S. Bassi

chapter 2|70 pages

Toward Understanding the Intelligent Properties of Biological Macromolecules

Implications for Their Design into Biosensors
ByKenneth A. Marx

section Section II|2 pages

Material Design and Selection

chapter 3|10 pages

Molecular Film–Assembled Detection System for Biosensors by Layer-by-Layer Adsorption

ByShin-ichiro Suye, Haitao Zheng, Hiroaki Sakamoto

chapter 4|37 pages

Nanotubes and Nanowires for Biosensing

From Basic Science to Applications
ByXueliang Sun, Chen-Zhong Li

chapter 5|16 pages

Conducting Polymer Nanowire-Based Bio-Field Effect Transistor for Label-Free Detection

ByAdam K. Wanekaya, Wilfred Chen, Nosang V. Myung, Ashok Mulchandani

chapter 6|33 pages

Optical Methods of Single Molecule Detection and Applications in Biosensors

ByAnna Shahmuradyan, Ulrich J. Krull

section Section III|1 pages

Biosensor Design and Fabrication

chapter 7|121 pages

Porous Silicon in Biosensing Applications

ByBenjamin L. Miller

chapter 8|18 pages

The Challenge of Human Skin

Engineering the Biotic/Abiotic Interface
ByPuneet Khanna, Steven Hoath, Rod Smallwood, Shekhar Bhansali

chapter 9|31 pages

Nanoscale Optical Biosensors and Biochips for Cellular Diagnostics

ByEric R. Languirand, Daniel S. Kazal, Steven A. Lowery, Brian M. Cullum

section Section IV|2 pages


chapter 11|48 pages

High Information Content Physiological Biosensors

Nerve Cell Networks on Microelectrode Arrays
ByGuenter W. Gross, Joseph J. Pancrazio, Kamakshi Gopal

chapter 12|44 pages

Bacteriorhodopsin Protein

From a Biological Proton Pump to Functionalizing Photo-Electro-Chemical Transducers
ByKhaled M. Al-Aribe

chapter 13|19 pages

Color-Sensitive Biosensors for Imaging Applications

ByLasse Lensu, Michael Frydrych, Jussi Parkkinen, Sinikka Parkkinen, Timo Jaaskelainen

chapter 14|17 pages

Printable Electronics for Biosensing

ByDogan Sinar

chapter 15|13 pages

Passive Biosensors for Flexible Hybrid-Printed Electronic Systems

ByChristian Fayomi, Herve Achigui Facpong, Gordon W. Roberts

section Section V|2 pages

Applications in Detection and Monitoring

chapter 16|26 pages

Optical Biosensors in Foodborne Pathogen Detection

ByAtul K. Singh, Arun K. Bhunia

chapter 17|18 pages

Multiarray Biosensors for Toxicity Monitoring

ByOmowunmi A. Sadik, Silvana Andreescu, Jason Karasinski

chapter 18|16 pages

Biosensors for the Detection of Emerging Plants and Animals Fungal Pathogens

ByRoland Miller, Idris Yazgan, Omowunmi A. Sadik

chapter 19|23 pages

Droplet Microfluidics

ByXiaoming Chen, Carolyn L. Ren

chapter 20|24 pages

Battery-Free Wireless Sensors for Healthcare and Food Quality Monitoring

ByBradley D. Nelson, Salil Sidharthan Karipott, Samerender Nagam Hanumantharao, Smitha Rao, Keat Ghee Ong

chapter 21|13 pages

Perspectives on the Future of Biosensor Technology

ByAmarjeet S. Bassi, George K. Knopf