Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging.

The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion.

  • Comprehensive collection of reviews of recent research
  • Introductory materials in mechanics, biology, and statistics
  • Discussion of pioneering and emerging mechanobiology concepts
  • Presentation of cutting-edge mechanobiology research findings across various fields and organ systems
  • End of chapter study questions, available online

Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

section Section I|1 pages

Tools for Mechanobiology

chapter 1|20 pages

An Introductory Guide to Solid Mechanics

BySarah C. Baxter

chapter 2|22 pages

Fluid Mechanics

ByTiffany Camp, Richard Figliola

chapter 3|28 pages

Molecular Analysis in Mechanobiology

ByKen Webb, Jeoung Soo Lee

chapter 4|16 pages

Introductory Statistics Refresher

ByJulia L. Sharp, Patrick D. Gerard

chapter 5|26 pages

Introductory Statistical Experimental Designs

ByJulia L. Sharp, Patrick D. Gerard

chapter 6|35 pages

Imaging Fibrillar Collagen with Optical Microscopy

ByTong Ye, Peng Chen, Yang Li, Xun Chen

section Section II Part 1|1 pages

Cardiovascular Systems

chapter 7|24 pages

Centralized Endothelial Mechanobiology, Endothelial Dysfunction, and Atherosclerosis

ByIan Chandler Harding, Eno Essien Ebong

chapter 8|19 pages

Effects of Endovascular Intervention on Vascular Smooth Muscle Cell Function

ByBrad Winn, Bethany Acampora, Jiro Nagatomi, Martine LaBerge

chapter 9|11 pages

Effects of Pressure on Vascular Smooth Muscle Cells

BySheila Nagatomi, Harold A. Singer, Rena Bizios

chapter 10|19 pages

Mechanobiology of Heart Valves

ByJoshua D. Hutcheson, Michael P. Nilo, W. David Merryman

chapter 11|12 pages

Mechanobiology of Cardiac Fibroblasts

ByPeter A. Galie, Jan P. Stegemann

chapter 12|37 pages

Mechanobiological Evidence for the Control of Neutrophil Activity by Fluid Shear Stress

ByHainsworth Y. Shin, Xiaoyan Zhang, Ayako Makino, Geert W. Schmid-Schönbein

section Section II Part 2|1 pages

Musculoskeletal Systems

chapter 13|28 pages

Skeletal Mechanobiology

ByAlesha B. Castillo, Christopher R. Jacobs

chapter 14|22 pages

Mechanical Control of Bone Remodeling

ByNatasha Case, Janet Rubin

chapter 15|24 pages

Cartilage Mechanobiology

ByHai Yao, Yongren Wu, Xin L. Lu

chapter 16|22 pages

Cell Mechanobiology: The Forces Applied to Cells and Generated by Cells

ByBin Li, Jeen-Shang Lin, James H.-C. Wang

section Section II Part 3|1 pages

Other Organs & Common Mechanisms

chapter 17|27 pages

Pulmonary Vascular Mechanobiology

ByDiana M. Tabima Martinez, Naomi C. Chesler

chapter 18|21 pages

Lung Mechanobiology

ByDaniel J. Tschumperlin, Francis Boudreault, Fei Liu

chapter 19|22 pages

Mechanical Signaling in the Urinary Bladder

ByAruna Ramachandran, Ramaswamy Krishnan, Rosalyn M. Adam

chapter 20|17 pages

Mechanobiology of Bladder Urothelial Cells

ByShawn Olsen, Kevin Champaigne, Jiro Nagatomi

chapter 22|21 pages

Mechanobiology in the Reproductive Tract

ByJulie Anne MacDonald, Dori C. Woods

chapter 23|20 pages

Mechano-Regulation of Fibrillar Collagen Turnover by Fibroblasts

ByJesse D. Rogers, Amirreza Yeganegi, William J. Richardson

chapter 24|21 pages

Mechanobiology in Health and Disease in the Central Nervous System

ByTheresa A. Ulrich, Sanjay Kumar

chapter 25|20 pages

Hydrostatic Pressure and Its Role in Physiology and Pathology

ByCody Dunton, Jiro Nagatomi

section Section II Part 4|1 pages

Transformative and Translational Mechanobiology

chapter 26|23 pages

Mechanostimulation in Bone and Tendon Tissue Engineering

BySamuel B. VanGordon, Warren Yates, Vassilios I. Sikavitsas

chapter 27|20 pages

Mesenchymal Stem Cell Mechanobiology

ByWen Li Kelly Chen, Craig A. Simmons

chapter 28|21 pages

The Use of Microfluidic Technology in Mechanobiology Research

ByBrittany McGowan, Sachin Jambovane, Jong Wook Hong, Jiro Nagatomi

chapter 29|20 pages

Design of Abdominal Wall Hernioplasty Meshes Guided by Mechanobiology and the Wound Healing Response

ByShawn J. Peniston, Karen J.L. Burg, Shalaby W. Shalaby