An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art and the future of these fields.


Key selling features:

  • Describes various bioreactors or stem cell culturing systems
  • Reviews methods for stem cell expansion and differentiation for neural, cardiac, hemopoietic, mesenchymal, hepatic and other tissues cell types
  • Distinguishes different types of bioreactors intended for different operational scales of tissue engineering and cellular therapies
  • Includes contributions from an international team of leaders in stem cell research

chapter 1|24 pages

Large-Scale Culture of 3D Aggregates of Human Pluripotent Stem Cells

ByElena F. Jacobson, Emmanuel S. Tzanakakis

chapter 2|21 pages

Bioreactors for Human Pluripotent Stem Cell Expansion and Differentiation

ByCarlos A.V. Rodrigues, Mariana Branco, Diogo E.S. Nogueira, Teresa P. Silva, Ana Rita Gomes, Maria Margarida Diogo, Joaquim M. S. Cabral

chapter 3|16 pages

Differentiation of Human Pluripotent Stem Cells for Red Blood Cell Production

ByMark C. Allenby, Susana Brito dos Santos, Nicki Panoskaltsis, Athanasios Mantalaris

chapter 4|33 pages

3D Strategies for Expansion of Human Cardiac Stem/Progenitor Cells

ByMaria João Sebastião, Bernardo Abecasis, Manuel J.T. Carrondo, Paula M. Alves, Patrícia Gomes-Alves, Margarida Serra

chapter 5|38 pages

Bioreactor Protocols for the Expansion and Differentiation of Human Neural Precursor Cells in Targeting the Treatment of Neurodegenerative Disorders

ByArindom Sen, Behnam A. Baghbaderani, Michael S. Kallos, Ivar Mendez, Leo A. Behie

chapter 6|29 pages

Bioprocessing of Human Stem Cells for Therapeutic Use through Single-Use Bioreactors

ByAletta C. Schnitzler, Mark Lalli, Manjula Aysola, Janmeet Anant, Julie Murrell

chapter 7|36 pages

Bioreactors for the Cultivation of Hematopoietic Stem and Progenitor Cells

ByMarta H.G. Costa, Frederico Castelo Ferreira, Joaquim M. S. Cabral, Cláudia Lobato da Silva

chapter 8|42 pages

Quality Manufacturing of Mesenchymal Stem/Stromal Cells Using Scalable and Controllable Bioreactor Platforms

BySunghoon Jung, Krishna M. Panchalingam, Brian Lee, Leo A. Behie

chapter 9|26 pages

Bioreactor Sensing and Monitoring for Cell Therapy Manufacturing

ByIoannis Papantoniou, Toon Lambrechts, Priyanka Gupta, Sébastien de Bournonville, Niki Loverdou, Liesbet Geris, Jean-Marie Aerts

chapter 10|32 pages

Bioreactors for Tendon Tissue Engineering

Challenging Mechanical Demands Towards Tendon Regeneration
ByAna I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Rui L. Reis, Manuela E. Gomes

chapter 11|27 pages

Liver Tissue Engineering

BySara Morini, Natalia Sánchez-Romero, Iris Plá Palacín, Pilar Sainz Arnal, Manuel Almeida, Laurens Verscheijden, Joana I. Almeida, Alberto Lue, Sara Llorente, Helen Almeida, Pablo Royo Dachary, Agustín García Gil, Trinidad Serrano-Aulló, Pedro M. Baptista