Chronic pain places a tremendous burden on both the patient and the healthcare system.  The use of opioids to address pain has resulted in negative impacts. As practitioners work to undo the current opioid crisis, options to manage pain need a new approach. Advanced Therapeutics in Pain Medicine offers pioneering approaches to this intransigent problem providing a functional medicine approach toward treating pain.

This book is dedicated to the advancement of non-opioid therapeutic options that offer real progress in reaching a future of better pain management. With an emphasis on pathophysiology, chapters review various types of pain and propose comprehensive treatment plans. These include manual therapies, novel pharmacologic and plant-based approaches, hormonal effects on pain pathways, as well as psychological and lifestyle interventions.


·       Written by a multi-discplinary team, the book provides clinicians with multiple non-opioid treatment considerations.

·       Enables practitioners to shift from a “one size fits all’ treatment approach toward individualized patient care.

·       Includes case studies to help educate the provider on how to implement treatment plans in practice.

Written by a team of physicians, pharmacists, psychologists and researchers, this important book offers a much needed step forward in optimizing pain care and benefits practitioners who care for patients experiencing chronic pain.


chapter 1|8 pages

Physiology of the Pain System

ByMatthew Bennett, Sahar Swidan

chapter 2|16 pages

Neuro–Endocrine–Immune Dysfunction in the Chronic Pain Patient

ByMatthew Bennett

chapter 3|10 pages

The Opioid Epidemic

ByMatthew Bennett

chapter 4|30 pages

Endogenous Cannabinoid Receptors and Medical Cannabis

ByJeffrey S. Block

chapter 5|12 pages

Sex Hormones and Pain Control

ByPamela W. Smith

chapter 6|36 pages

Managing Pain in the Presence of Autoimmune Disease

ByDavid Bilstrom

chapter 7|22 pages


A Comprehensive Perspective
BySahar Swidan, Kai-Uwe Kern

chapter 8|18 pages

A Functional Approach to Gynecologic Pain

Integrative Gynecology for the Non-Gynecologist
ByRandy A. Fink

chapter 9|24 pages

Headache Disorders

ByTodd D. Rozen

chapter 10|16 pages


Advancing Pain Diagnosis and Treatment by Rethinking Anatomy and Biomechanics
ByBradley D. Fullerton

chapter 11|18 pages

Myofascial Trigger Points, Sensitization, and Chronic Musculoskeletal Pain

Evaluation and Management
ByVy Phan, Jay P. Shah, Pamela Stratton

chapter 12|12 pages

Mycotoxins and Tick-Borne Disease

Increasingly Common Causes of Unexplained Chronic Pain
ByEllen Antoine, Scott Antoine

chapter 13|20 pages

Regenerative Medicine in Pain Management

BySharon McQuillan, Rafael Gonzalez

chapter 14|12 pages

Adenine Dinucleotide

Past, Present, and Future
ByRichard F. Mestayer, Hyla Cass

chapter 15|10 pages

Ketamine Use in Pain Management

BySahar Swidan, Charles E. Schultz

chapter 16|10 pages

The Limbic System, Oxytocin, and Pain Management

BySahar Swidan, Charles E. Schultz

chapter 17|16 pages

Low-Dose Naltrexone

Immune and Inflammatory Mediator Extraordinaire
BySahar Swidan

chapter 18|10 pages

Topical Pain Medications and Their Role in Pain Management

BySahar Swidan, Mara Rubin

chapter 19|22 pages

Herbal and Supplement Use in Pain Management

BySahar Swidan, Mara Rubin

chapter 20|8 pages


A Novel Fatty Acid in the Treatment of Pain
BySahar Swidan

chapter 21|14 pages

Lifestyle and Its Relationship to Pain

ByHal S. Blatman

chapter 22|14 pages

Developing Education and Treatment Protocols for Substance Use Disorders That Are Socially Responsible, Accountable, and Integrated

Recovery Engagement—Recognize and Treat
ByBrian Spitsbergen

chapter 23|6 pages

Detoxification Strategies

ByJennifer Kljajic, Ahmed Zaafran

chapter 24|6 pages

Naloxone Use in the Opioid Epidemic

BySahar Swidan, Ellen Klepack

chapter 25|12 pages

Psychological Intervention

Cognitive-Behavioral Therapy
BySamantha Rafie, Sarah Rispinto, Sarah Martin