Oxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions.


  • Defines essential redox biology reactions and concepts in exercise physiology
  • Assesses key redox parameters in an in vivo human exercise context
  • Identifies the challenges, opportunities and boundaries of current knowledge
  • Includes a critique of the underlying mechanisms
  • Summarises examples of translationally important research relating to disease states

Related Titles

Draper, N. & H. Marshall. Exercise Physiology for Health and Sports Performance (ISBN 978-0-2737-7872-1)

Wackerhage, H., ed. Molecular Exercise Physiology: An Introduction (ISBN 978-0-4156-0788-9)

chapter Chapter One|10 pages

Introduction to Oxidative (Eu)stress in Exercise Physiology

ByGareth W. Davison, James N. Cobley

chapter Chapter Two|12 pages

Measuring Oxidative Damage and Redox Signalling

Principles, Challenges, and Opportunities
ByJames N. Cobley, Gareth W. Davison

chapter Chapter Three|17 pages

Exercise Redox Signalling

From ROS Sources to Widespread Health Adaptation
ByRuy A. Louzada, Jessica Bouviere, Rodrigo S. Fortunato, Denise P. Carvalho

chapter Chapter Four|17 pages

Oxygen Transport

A Redox O2dyssey
ByP.N. Chatzinikolaou, N.V. Margaritelis, A.N. Chatzinikolaou, V. Paschalis, A.A. Theodorou, I.S. Vrabas, A. Kyparos, M.G. Nikolaidis

chapter Chapter Five|12 pages

Mitochondrial Redox Regulation in Adaptation to Exercise

ByChristopher P. Hedges, Troy L. Merry

chapter Chapter Six|14 pages

Basal Redox Status Influences the Adaptive Redox Response to Regular Exercise

ByEthan L. Ostrom, Tinna Traustadóttir

chapter Chapter Seven|10 pages

Time to ‘Couple’ Redox Biology with Exercise Immunology

ByAlex J. Wadley, Steven J. Coles

chapter Chapter Eight|8 pages

Exercise and RNA Oxidation

ByEmil List Larsen, Kristian Karstoft, Henrik Enghusen Poulsen

chapter Chapter Nine|12 pages

Exercise and DNA Damage

Considerations for the Nuclear and Mitochondrial Genome
ByJosh Williamson, Gareth W. Davison

chapter Chapter Ten|8 pages

Nutritional Antioxidants for Sports Performance

ByJamie N. Pugh, Graeme L. Close

chapter Chapter Eleven|13 pages

Antioxidant Supplements and Exercise Adaptations

ByShaun A. Mason, Lewan Parker, Adam J. Trewin, Glenn D. Wadley

chapter Chapter Twelve|15 pages

Nitric Oxide Biochemistry and Exercise Performance in Humans

Influence of Nitrate Supplementation
ByStephen J. Bailey, Andrew M. Jones

chapter Chapter Thirteen|13 pages

(Poly)phenols in Exercise Performance and Recovery

More Than an Antioxidant?
ByTom Clifford, Glyn Howatson

chapter Chapter Fourteen|15 pages


A Strategy to Target Oxidative Stress in Cancer
ByAmélie Rébillard, Cindy Richard, Suzanne Dufresne

chapter Chapter Fifteen|9 pages

Oxidative Stress and Exercise Tolerance in Cystic Fibrosis

ByCassandra C. Derella, Adeola A. Sanni, Ryan A. Harris

chapter Chapter Sixteen|15 pages

Ageing, Neurodegeneration and Alzheimer's Disease

The Underlying Role of Oxidative Distress
ByRichard J. Elsworthy, Sarah Aldred

chapter Chapter Seventeen|13 pages

Exercise, Metabolism and Oxidative Stress in the Epigenetic Landscape

ByGareth W. Davison, Colum P. Walsh